Norton R, Roberts B, Freeman M, Wilson M, Ashhurst-Smith C, Lock W, Brookes D, La Brooy J
Townsville General Hospital, Queensland, Australia.
FEMS Immunol Med Microbiol. 1998 Jan;20(1):37-44. doi: 10.1111/j.1574-695X.1998.tb01109.x.
Eighteen cases of culture positive melioidosis caused by Burkholderia pseudomallei, were seen in four geographically separate communities in North Queensland, Australia. The genetic inter-relatedness of the clinical isolates were compared utilising random amplification of polymorphic DNA (RAPD) and multilocus enzyme electrophoresis (MEE). The isolates segregated into two groups that correlated with clinical presentation rather than geographical location. This is the first described association between the varied clinical presentations of this condition and specific molecular type. If proven on larger studies, this may further our understanding of the pathogenesis of this important condition.
在澳大利亚北昆士兰四个地理位置分散的社区中，共发现18例由类鼻疽伯克霍尔德菌引起的培养阳性类鼻疽病例。利用随机扩增多态性DNA（RAPD）和多位点酶电泳（MEE）对临床分离株的遗传相关性进行了比较。分离株分为两组，这与临床表现相关，而非地理位置。这是首次描述这种疾病的不同临床表现与特定分子类型之间的关联。如果在更大规模的研究中得到证实，这可能会进一步加深我们对这种重要疾病发病机制的理解。
