吸入二氧化碳及静脉输注高碳酸血症血液时的通气反应。

Ventilatory response to CO2 inhalation and intravenous infusion of hypercapnic blood.

作者信息

Linton R A, Miller R, Cameron I R

出版信息

Respir Physiol. 1976 May;26(3):383-94. doi: 10.1016/0034-5687(76)90008-6.

Abstract

The ventilatory responses to intravenous infusion of hypercapnic blood (equilibrated with 80% CO2: 20% O2) and inhaled CO2 (1.5-2.0% CO2) have been compared in anaesthetized rabbits. A control infusion of blood equilibrated with 4% CO2: 21% O2 produced no change in V, PaCO2 or PaO2. The ventilatory response to a given rise in PaCO2, deltaV - (delta PaCO2)-1, was greater during infusion of hypercapnic blood (69 +/- 33 ml-min-1-mm Hg-1, mean +/- SD) than during CO2 inhalation (28 +/- 16 ml-min-1-min Hg-1, P less than 0.01). There was no difference between the rates at which the final levels of ventilation were reached during inhalation of CO2 or infusion of hypercapnic blood. It is suggested that the difference between the responses may be accounted for by differences in the pattern of PaCO2 oscillations in the two situations.

摘要

在麻醉兔中比较了静脉输注高碳酸血症血液（与80%二氧化碳：20%氧气平衡）和吸入二氧化碳（1.5 - 2.0%二氧化碳）时的通气反应。用与4%二氧化碳：21%氧气平衡的血液进行对照输注，未引起分钟通气量（V）、动脉血二氧化碳分压（PaCO2）或动脉血氧分压（PaO2）的变化。在输注高碳酸血症血液期间，对给定的PaCO2升高的通气反应，即△V/（△PaCO2），大于吸入二氧化碳期间（分别为69±33 ml·min-1·mmHg-1和28±16 ml·min-1·mmHg-1，P＜0.01）。在吸入二氧化碳或输注高碳酸血症血液期间，达到最终通气水平的速率没有差异。提示两种情况下反应的差异可能是由于PaCO2振荡模式的不同所致。