Hossain A
J Trop Pediatr. 1989 Aug;35(4):171-4. doi: 10.1093/tropej/35.4.171.
The seroepidemiology of infection due to herpes simplex type 1 (HSV-1) and varicella-zoster (VZV) viruses was investigated in 224 Saudi children aged from under 1 year to 15 years and 452 adults (healthy male blood donors and pregnant women) using a presently available sensitive indirect immunofluorescence technique to detect antibodies to these viruses in order to determine the age of primary infection. Age-specific prevalence of IgG antibodies to HSV-1 and VZV showed a progressive increase with age in both males and females with no obvious sex-related variation in the level. The overall prevalence of antibodies was 60 per cent for HSV-1 and 68 per cent for VZV in children whereas about 90 per cent of the adults showed the presence of antibodies to both viruses. Virological and serological confirmation of two cases in children of herpes simplex encephalitis (HSE) due to HSV-1 and VZV reactivation in two adults is described.
采用目前可用的灵敏间接免疫荧光技术，对224名年龄在1岁以下至15岁的沙特儿童以及452名成年人（健康男性献血者和孕妇）进行了1型单纯疱疹病毒（HSV-1）和水痘-带状疱疹病毒（VZV）感染的血清流行病学调查，以检测针对这些病毒的抗体，从而确定初次感染的年龄。HSV-1和VZV IgG抗体的年龄特异性患病率在男性和女性中均随年龄逐渐增加，且水平无明显性别差异。儿童中HSV-1抗体的总体患病率为60%，VZV抗体的总体患病率为68%，而约90%的成年人显示同时存在这两种病毒的抗体。文中描述了两名儿童因HSV-1导致单纯疱疹性脑炎（HSE）以及两名成年人VZV再激活的病毒学和血清学确诊情况。
