Jones D T
Department of Biological Sciences, University of Warwick, Coventry, UK.
FEBS Lett. 1998 Feb 27;423(3):281-5. doi: 10.1016/s0014-5793(98)00095-7.
A reliable and widely used transmembrane protein structure prediction algorithm was applied to five representative genomic sequence data sets in order to re-examine the hypothesis that in contrast to globular proteins there are no favored transmembrane protein fold families. When the number of predicted membrane spanning segments and the topology of these segments is taken into account then definite biases are observed which suggest that certain transmembrane topologies are significantly more common than others.
一种可靠且广泛使用的跨膜蛋白结构预测算法被应用于五个代表性的基因组序列数据集，以便重新审视这一假设：与球状蛋白不同，不存在偏好的跨膜蛋白折叠家族。当考虑预测的跨膜片段数量及其拓扑结构时，会观察到明确的偏差，这表明某些跨膜拓扑结构比其他结构明显更常见。
