Amyes S G
Department of Medical Microbiology, The Medical School, University of Edinburgh, Scotland.
Chest. 1998 Mar;113(3 Suppl):228S-232S. doi: 10.1378/chest.113.3_supplement.228s.
The early-onset hospital pulmonary gram-negative infections may respond to ciprofloxacin and co-amoxiclav without significant resistance development. Penicillin-resistant Streptococcus pneumoniae may be treated with macrolides, fluoroquinolones, and glycopeptides. The late-onset hospital pathogens all seem to have developed resistance to cephalosporins, so greater reliance is now made on the fluoroquinolones and carbapenems when aminoglycoside therapy is considered undesirable.
