Salín-Pascual R J, Galicia-Polo L, Drucker-Colín R
Servicio de Investigación del Hospital Psiquiátrico Fray Bernardino Alvarez, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City.
J Clin Psychiatry. 1997 Aug;58(8):348-50. doi: 10.4088/jcp.v58n0803.
The purpose was to examine the effect of the antidepressant drug venlafaxine on sleep architecture and periodic leg movements of sleep (PLMS) in normal volunteers.
Eight normal volunteers were studied under laboratory sleep conditions as follows: 1 acclimatization night, 1 baseline night, and 4 consecutive nights of venlafaxine p.o. administration (75 mg during the first 2 nights and 150 mg the last 2 nights).
Venlafaxine increased both wake time and sleep stage I. Sleep stages II and III were reduced. REM sleep time was reduced after the first venlafaxine dose, and, by the fourth night, REM sleep was completely suppressed in all volunteers. Six of the eight volunteers showed PLMS at a frequency above 25 per hour.
Venlafaxine produces several sleep disturbances, which include abnormal leg movements.
目的是研究抗抑郁药物文拉法辛对正常志愿者睡眠结构和睡眠期周期性肢体运动（PLMS）的影响。
八名正常志愿者在实验室睡眠条件下接受如下研究：1个适应夜、1个基线夜以及连续4晚口服文拉法辛（前两晚75毫克，后两晚150毫克）。
文拉法辛增加了清醒时间和睡眠一期。睡眠二期和三期减少。首次服用文拉法辛后快速眼动睡眠（REM）时间减少，到第四晚时，所有志愿者的快速眼动睡眠完全被抑制。八名志愿者中有六名每小时的PLMS频率超过25次。
文拉法辛会导致多种睡眠障碍，其中包括腿部异常运动。
