Robins J B, Mason G C, Watters J, Martinez D
Department of Feto-Maternal Medicine, The General Infirmary at Leeds, UK.
Prenat Diagn. 1998 Feb;18(2):173-7. doi: 10.1002/(sici)1097-0223(199802)18:2<173::aid-pd227>3.0.co;2-a.
Cerebellar hypoplasia is a prominent feature of fetal brain pathology. The lesion is rarely isolated or asymmetric. Various aetiological factors have been proposed. The frequency of cerebellar hypoplasia as a congenital defect in humans is unknown. A single case is described of unilateral cerebellar hypoplasia with intact vermis that was detected on prenatal ultrasound examination. Changes in the appearance of the abnormality over the course of the pregnancy raised the possibility of a disruptive vascular aetiology with destruction of normally formed structures. Prenatal ultrasound, post-delivery cranial ultrasound, and MRI images are presented to support the hypothesis.
小脑发育不全是胎儿脑部病理学的一个显著特征。该病变很少是孤立的或不对称的。已经提出了各种病因。小脑发育不全作为人类先天性缺陷的发生率尚不清楚。本文描述了一例产前超声检查发现的单侧小脑发育不全且蚓部完整的病例。孕期该异常外观的变化增加了血管病因导致正常形成的结构破坏的可能性。文中展示了产前超声、产后头颅超声和磁共振成像（MRI）图像以支持这一假说。
