Pollak M N
Department of Medicine, Lady Davis Research Institute of the Jewish General Hospital and McGill University, Montreal, Quebec, Canada.
Breast Cancer Res Treat. 1998 Feb;47(3):209-17. doi: 10.1023/a:1005950916707.
Insulin-like growth factors (IGFs) are mitogenic and anti-apoptotic peptides that influence the proliferative behavior of many cell types, including normal and transformed breast epithelial cells. IGF-I has properties of both a tissue growth factor and a systemic hormone: there is evidence that IGF bioactivity in tissues is influenced not only by local factors such as tissue expression of IGFs, IGF binding proteins (IGFBPs), and IGFBP proteases, but also by factors that regulate whole-body IGF physiology and circulating IGF-I levels. Experimental evidence that interventions that reduce circulating IGF-I levels reduce proliferation of breast neoplasms has raised interest in the possibility of developing novel endocrine therapies that target the growth hormone/IGF-I axis. Furthermore, influences of the growth hormone/IGF-I axis on normal breast epithelial cells may underlie recent epidemiological observations that suggest that premenopausal women with high circulating IGF-I level are at increased risk for breast cancer. These studies suggest that the growth hormone/IGF-I axis deserves investigation as a possible target for novel breast cancer prevention strategies.
胰岛素样生长因子（IGFs）是有丝分裂原性和抗凋亡性的肽，可影响多种细胞类型的增殖行为，包括正常和转化的乳腺上皮细胞。IGF-I兼具组织生长因子和全身激素的特性：有证据表明，组织中的IGF生物活性不仅受局部因素影响，如IGFs的组织表达、IGF结合蛋白（IGFBPs）和IGFBP蛋白酶，还受调节全身IGF生理学和循环IGF-I水平的因素影响。降低循环IGF-I水平的干预措施可减少乳腺肿瘤增殖的实验证据，引发了人们对开发针对生长激素/IGF-I轴的新型内分泌疗法可能性的兴趣。此外，生长激素/IGF-I轴对正常乳腺上皮细胞的影响，可能是近期流行病学观察结果的基础，这些观察结果表明，循环IGF-I水平高的绝经前女性患乳腺癌的风险增加。这些研究表明，生长激素/IGF-I轴作为新型乳腺癌预防策略的可能靶点值得研究。
