Kuchner E F, Hansebout R R
Surg Neurol. 1976 Dec;6(6):371-6.
Canine spinal cords were compressed at T-13 by an epidural balloon maintained at 160 mm Hg for one hour. After seven weeks, mean motor ratings of dogs treated with either parenteral dexamenthasone or non-irrigative local hypothermia (on the dorsal dura mater at 6 degrees C for four hours) indicated ability to walk well, whereas untreated dogs could not walk. A third treatment group received both dexamethasone and delayed local hypothermia; this group performed poorly in early weeks, but eventually surpassed the other groups and became the only group to attain a final mean motor rating which was superior to that of controls at a significance level of p less than .01. Hypothermia was induced by means of a miniature epidural heat exchanger which eliminated tissue irrigation as a possible experimental variable. The possible mechanisms of action of hypothermia are reviewed.
犬类脊髓在T-13处被一个维持在160毫米汞柱的硬膜外球囊压迫一小时。七周后，接受肠胃外给予地塞米松或非灌注性局部低温治疗（在硬脊膜背侧6摄氏度持续四小时）的犬类的平均运动评分表明它们能够正常行走，而未治疗的犬类则无法行走。第三个治疗组同时接受了地塞米松和延迟局部低温治疗；该组在最初几周表现不佳，但最终超过了其他组，成为唯一一组最终平均运动评分在p小于0.01的显著水平上优于对照组的组。低温是通过一个微型硬膜外热交换器诱导产生的，该热交换器消除了组织灌注这一可能的实验变量。文中对低温可能的作用机制进行了综述。
