Minsky B D
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Semin Radiat Oncol. 1998 Jan;8(1):30-5. doi: 10.1016/s1053-4296(98)80034-9.
The advantage of preoperative therapy in patients with clinically resectable transmural rectal cancer is to increase sphincter preservation while obtaining a high likelihood of local control. In patients who undergo a prospective clinical assessment and are declared to require an abdominoperineal resection, preoperative radiation therapy, either alone or when combined with chemotherapy, allows approximately 80% of patients to undergo a low anterior resection with or without colo anal anastomosis. The majority have good-to-excellent sphincter function. This conservative approach may be an alternative to an abdominoperineal resection in selected patients.
对于临床可切除的透壁性直肠癌患者，术前治疗的优势在于在获得高局部控制率的同时增加括约肌保留率。在接受前瞻性临床评估并被判定需要行腹会阴联合切除术的患者中，单独术前放疗或放疗联合化疗可使约80%的患者接受低位前切除术，可选择或不选择结肠肛管吻合术。大多数患者的括约肌功能良好至极佳。这种保守方法可能是某些特定患者腹会阴联合切除术的替代方案。
