Verdoux H, van Os J, Maurice-Tison S, Gay B, Salamon R, Bourgeois M
Department of Psychiatry, University Victor Segalen Bordeaux, France.
Schizophr Res. 1998 Feb 9;29(3):247-54. doi: 10.1016/s0920-9964(97)00095-9.
It has been hypothesized that late adolescence and early adulthood might be a brain developmental stage favoring the clinical expression of psychotic symptoms in psychiatric or neurological diseases. The aim of the present survey was to examine the relationship between age and delusional ideation in a sample of subjects with no psychiatric disorder. The survey was carried out with the Aquitaine Sentinel Network of general practitioners. Consecutive practice attenders were invited to complete the PDI-21 (Peters Delusional Inventory 21 items), a self-report questionnaire designed to measure delusional ideation in the normal population. The study concerned 444 patients who had no lifetime history of psychiatric disorder and who completed the PDI-21. A principal component analysis of the PDI-21 items was performed in order to identify delusional dimensions. An age-related decrease in the likelihood to report delusional ideas was found, younger subjects scoring higher on most dimensions of delusional ideation, such as 'persecution', 'thought disturbance', 'grandiosity' and 'paranormal beliefs'. 'Religiosity' was the only dimension positively associated with age. The results suggest that there may be a physiological neurodevelopmental stage favouring the expression of psychosis proneness in normal subjects, and support the hypothesis that the association between age and positive psychotic symptoms in functional and organic psychoses may be linked to the interaction between normal brain maturational processes and cerebral abnormalities involved in the aetiology of functional and organic psychoses.
有假说认为，青春期晚期和成年早期可能是一个大脑发育阶段，有利于精神疾病或神经疾病中精神病症状的临床表现。本次调查的目的是在无精神疾病的受试者样本中研究年龄与妄想观念之间的关系。该调查是通过阿基坦全科医生哨点网络进行的。连续的就诊者被邀请完成PDI - 21（彼得斯21项妄想量表），这是一份旨在测量正常人群中妄想观念的自我报告问卷。该研究涉及444名无精神疾病终生史且完成了PDI - 21的患者。对PDI - 21项目进行了主成分分析，以确定妄想维度。结果发现，报告妄想观念的可能性与年龄呈负相关，较年轻的受试者在妄想观念的大多数维度上得分更高，如“迫害妄想”、“思维紊乱”、“夸大妄想”和“超自然信念”。“宗教信仰”是唯一与年龄呈正相关的维度。研究结果表明，可能存在一个生理神经发育阶段，有利于正常受试者中易患精神病倾向的表达，并支持以下假说：在功能性和器质性精神病中，年龄与阳性精神病症状之间的关联可能与正常大脑成熟过程和功能性及器质性精神病病因中涉及的大脑异常之间的相互作用有关。
