Aoyama N, Kinoshita Y, Fujimoto S, Himeno S, Todo A, Kasuga M, Chiba T
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Am J Gastroenterol. 1998 Mar;93(3):311-6. doi: 10.1111/j.1572-0241.1998.00311.x.
Although physical stresses are known to induce peptic ulcers in the upper gastrointestinal tract, it remains controversial whether emotional stress can cause peptic ulcers. Therefore, we examined retrospectively the influence of the Hanshin-Awaji earthquake that occurred in Japan in January 1995 on the occurrence of peptic ulcer disease among noninjured residents.
Sixty-one hospitals, covering 70% of all endoscopy examinations performed in this area, joined the study and were divided into three areas according to the severity of the damage. A comparison was made between a group of 10,831 patients who underwent upper gastrointestinal endoscopy within 2 months after the earthquake and 16,100 who did so in the same hospitals during the corresponding period in 1994.
In the most devastated area, in spite of a dramatic decrease in the total number of endoscopies (50.0%), patients with gastric ulcer (GU) were increased in 1995, whereas those with duodenal ulcer were decreased, resulting in a higher ratio of gastric to duodenal ulcers than in 1994 (3.07 vs 1.88). In particular, there was a marked increase in bleeding GU. The mean age of patients with GU was significantly higher in 1995 than in 1994.
The Hanshin-Awaji earthquake-induced life event stress not only triggered but also exacerbated GU, particularly in the elderly.
虽然已知身体应激会诱发上消化道消化性溃疡，但情绪应激是否会导致消化性溃疡仍存在争议。因此，我们回顾性研究了1995年1月发生在日本的阪神 - 淡路大地震对未受伤居民消化性溃疡疾病发生情况的影响。
61家医院参与了该研究，这些医院进行了该地区70%的内镜检查，并根据受损严重程度分为三个区域。对地震后2个月内接受上消化道内镜检查的10831例患者与1994年同期在同一家医院接受检查的16100例患者进行了比较。
在受灾最严重的地区，尽管内镜检查总数大幅下降（50.0%），但1995年胃溃疡（GU）患者数量增加，而十二指肠溃疡患者数量减少，导致胃溃疡与十二指肠溃疡的比例高于1994年（3.07对1.88）。特别是出血性胃溃疡显著增加。1995年GU患者的平均年龄显著高于1994年。
阪神 - 淡路大地震引发的生活事件应激不仅引发了胃溃疡，还使其恶化，尤其是在老年人中。
