伴有抗浦肯野细胞抗体的副肿瘤性小脑变性与原发性输卵管癌相关。
Paraneoplastic cerebellar degeneration with anti-Purkinje cell antibody associated with primary tubal cancer.
作者信息
Matsushita H, Kodama S, Aoki Y, Tanaka K, Tanaka K, Saito N
机构信息
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
出版信息
Gynecol Obstet Invest. 1998;45(2):140-3. doi: 10.1159/000009942.
In patients with paraneoplastic cerebellar degeneration (PCD) due to gynecologic malignancies, a high titer of anti-Purkinje cell antibody (anti-Yo) has been found. Most patients, however, have limited oncologic disease at the time of onset of neurologic symptoms. We describe 2 cases of PCD due to tubal cancer with anti-Yo antibody. The onset of PCD occurred 4 and 14 months before the detection of cancer, respectively, and the presence of anti-Yo antibody facilitated early laparotomy in both cases. These patients, whose neurologic symptoms have not progressed, have survived without evidence of disease for 81 and 30 months since surgery, respectively. The presence of the anti-Yo antibody in patients with PCD warrants an aggressive approach to diagnosis and treatment of the underlying gynecologic cancer.
在因妇科恶性肿瘤导致的副肿瘤性小脑变性（PCD）患者中，已发现高滴度的抗浦肯野细胞抗体（抗Yo）。然而，大多数患者在神经症状出现时肿瘤疾病处于局限期。我们描述了2例因输卵管癌伴抗Yo抗体导致的PCD病例。PCD分别在癌症检测前4个月和14个月出现，抗Yo抗体的存在促使两例患者均早期接受了剖腹手术。这些患者的神经症状未进展，自手术以来分别已无病存活81个月和30个月。PCD患者中抗Yo抗体的存在值得对潜在的妇科癌症采取积极的诊断和治疗方法。
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