Eberle R, Black D H, Lehenbauer T W, White G L
Department of Infectious Diseases & Physiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, USA.
Lab Anim Sci. 1998 Feb;48(1):23-8.
Baboons in a captive breeding colony were monitored twice a year, and new additions were screened on arrival for shedding of Herpesvirus papio 2 (HVP2) and serologic reactivity to the agent. For 128 individual animals tested over a period of 1.5 years, shedding of infective virus was detected in 13 of 342 swab specimens (3.8%), each of these incidents representing shedding by a different animal. Among long-term colony animals, infective virus was recovered on only two occasions (5 of 236 swab specimens from five individuals). In all but one instance, animals shedding virus were infants, not adults, and all animals were shedding virus in the oral cavity. One of these five instances was an isolated case, but four (three infants and one adult) were clustered within a single breeding group. Molecular analyses of the HVP2 isolates from this cluster indicated that they likely arose from a single common source, probably the mother of one of the infants. None of 31 wild-caught baboons added to the colony during this period were found to be shedding infective virus, despite 93.5% of them being seropositive for HVP2. In contrast, 6 of 18 adult baboons (all seropositive) transferred into the colony from another breeding colony were found to be shedding HVP2 either orally (3 of 6) or genitally (3 of 6). In addition, 2 of 8 juvenile baboons in this shipment were found to be shedding virus in the oropharynx. Overall, 10 of 13 instances of HVP2 isolation were from the oropharynx rather than the genital tract, and 6 of 13 baboons shedding virus were infants or juveniles rather than adults. These results suggest that, although venereal transmission of HVP2 occurs among adult animals, oral infection of young, sexually immature baboons is not uncommon.
对一个圈养繁殖群体中的狒狒每年监测两次，新引入的狒狒在到达时进行筛查，检测是否有猴疱疹病毒2型（HVP2）脱落以及对该病原体的血清学反应。在1.5年的时间里对128只个体动物进行了检测，在342份拭子标本中有13份（3.8%）检测到感染性病毒脱落，每次事件代表不同动物的病毒脱落。在长期圈养群体动物中，仅在两次（来自五只个体的236份拭子标本中的5份）检测到感染性病毒。除一例之外，所有病毒脱落的动物均为幼崽而非成年动物，且所有动物的病毒脱落部位均在口腔。这五例中的一例为孤立病例，但有四例（三只幼崽和一只成年动物）集中在一个繁殖组内。对该集群中HVP2分离株的分子分析表明，它们可能源自单一共同来源，可能是其中一只幼崽的母亲。在此期间加入该群体的31只野生捕获狒狒中，尽管其中93.5%对HVP2血清呈阳性，但未发现有感染性病毒脱落。相比之下，从另一个繁殖群体转入该群体的18只成年狒狒（均为血清阳性）中有6只被发现有HVP2脱落，其中3只通过口腔（6只中的3只），3只通过生殖道（6只中的3只）。此外，这批运输中的8只幼年狒狒中有2只被发现口咽部有病毒脱落。总体而言，13例HVP2分离中有10例来自口咽部而非生殖道，13只病毒脱落的狒狒中有6只为幼崽或幼年动物而非成年动物。这些结果表明，尽管HVP2在成年动物中存在性传播，但幼年、性未成熟的狒狒经口感染并不罕见。
