Cromer J A, Hunter W L, Bennett P B
Undersea Biomed Res. 1976 Jun;3(2):139-50.
The components of the high pressure nervous syndrome (HPNS) have been clearly described previously. Animal studies of HPNS, however, have been characterized by nonstandardized definitions of the various HPNS parameters, based on visual observations. Where EEG's have been used in HPNS studies, the frequent occurrence of movement-induced artifact has made much of the data difficult to interpret. Because of these limitations, efforts to clarify the influence of environmental variables on the syndrome have led to varying results, especially with respect to the influence of temperature. The technique used in this study consistently yielded artifact-free EEGs from unanesthetized, moving rats during simulated heliox dives. Typical seizure patterns in the EEG recordings were combined with clinical seizure activity to define HPNS convulsion-threshold pressure (Pc). By manipulating body temperature artificially, three groups of rats were investigated--hypothermic, euthermic, and hyperthermic animals. An inverse relationship between body temperature and HPNS convulsion-threshold pressure was demonstrated.
高压神经综合征（HPNS）的组成部分此前已得到明确描述。然而，HPNS的动物研究存在各种HPNS参数定义不标准化的特点，这些定义基于视觉观察。在HPNS研究中使用脑电图（EEG）时，运动诱发伪影的频繁出现使得许多数据难以解释。由于这些局限性，为阐明环境变量对该综合征的影响所做的努力导致了不同的结果，尤其是在温度影响方面。本研究中使用的技术在模拟氦氧混合气潜水期间，始终能从未麻醉、活动的大鼠身上获取无伪影的脑电图。脑电图记录中的典型癫痫发作模式与临床癫痫发作活动相结合，以定义HPNS惊厥阈值压力（Pc）。通过人工控制体温，对三组大鼠进行了研究——体温过低、体温正常和体温过高的动物。结果表明体温与HPNS惊厥阈值压力之间呈反比关系。
