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Genetic complexity and Parkinson's disease. Deane Laboratory Parkinson Disease Research Group.

作者信息

Scott W K, Staijich J M, Yamaoka L H, Speer M C, Vance J M, Roses A D, Pericak-Vance M A

出版信息

Science. 1997 Jul 18;277(5324):387-8; author reply 389. doi: 10.1126/science.277.5324.387.

DOI:10.1126/science.277.5324.387
PMID:9518366
Abstract
摘要

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1
Genetic complexity and Parkinson's disease. Deane Laboratory Parkinson Disease Research Group.
Science. 1997 Jul 18;277(5324):387-8; author reply 389. doi: 10.1126/science.277.5324.387.
2
Genetic complexity and Parkinson's disease.
Science. 1997 Jul 18;277(5324):388-9; author reply 389.
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Mapping of a gene for Parkinson's disease to chromosome 4q21-q23.帕金森病一个基因定位于染色体4q21 - q23。
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The familial parkinsonism locus on chromosome 4 and idiopathic Parkinson's disease in Japan.日本4号染色体上的家族性帕金森病基因座与特发性帕金森病
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Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.载脂蛋白E4可能是导致帕金森病19号染色体连锁峰值的原因。
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A susceptibility gene for late-onset idiopathic Parkinson's disease.晚发性特发性帕金森病的一个易感基因。
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Genome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13.以性别和家族史作为协变量进行家族性腹主动脉瘤的全基因组扫描，提示存在遗传异质性，并确定与19号染色体长臂13区存在连锁关系。
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