抗精神病药恶性综合征后的小脑变性
Cerebellar degeneration following neuroleptic malignant syndrome.
作者信息
Lal V, Sardana V, Thussu A, Sawhney I M, Prabhakar S
机构信息
Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Postgrad Med J. 1997 Nov;73(865):735-6. doi: 10.1136/pgmj.73.865.735.
Abstract
A 55-year-old woman with a history of bipolar affective disorder developed hyperpyrexia, rigidity and depressed consciousness (neuroleptic malignant syndrome) after commencing neuroleptic therapy. On regaining consciousness, she was mute and had signs suggesting pancerebellar involvement. Hyperpyrexia, which is a cardinal feature of neuroleptic malignant syndrome, may have caused cerebellar damage. Neuroleptic malignant syndrome needs both early recognition and prompt treatment to obviate devastating complications.
摘要
一名患有双相情感障碍病史的55岁女性在开始使用抗精神病药物治疗后出现高热、强直和意识障碍（抗精神病药物恶性综合征）。恢复意识后，她缄默不语，并有提示全小脑受累的体征。高热是抗精神病药物恶性综合征的主要特征，可能导致了小脑损伤。抗精神病药物恶性综合征需要早期识别和及时治疗，以避免严重并发症。
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