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糖尿病大鼠膀胱中神经生长因子水平升高及背根神经节神经元肥大。

Increased levels of nerve growth factor in the urinary bladder and hypertrophy of dorsal root ganglion neurons in the diabetic rat.

作者信息

Steinbacher B C, Nadelhaft I

机构信息

University of Pittsburgh Department of Neuroscience and Otolaryngology, PA 15213, USA.

出版信息

Brain Res. 1998 Jan 26;782(1-2):255-60. doi: 10.1016/s0006-8993(97)01287-0.

Abstract

The level of nerve growth factor (NGF) in the streptozotocin (STZ)-diabetic rat was measured at approximately weekly intervals after STZ induction, using an ELISA assay technique. In addition, the area profiles of L6-S1, and L1-L2 dorsal root ganglion neurons (DRG), labelled by fast blue dye injected into the bladder, were measured at the same weekly intervals. Compared to control animals, the levels of NGF rose rapidly to a maximum at one week and then slowly declined over the next three weeks. The areas of the DRGs increased to a peak after which they also started to decline. The peak increase in DRG area profiles was delayed relative to the peak level of bladder NGF. The data suggest that bladder NGF is transported retrogradely to the DRG neurons where it transforms the cell economy to cause an increase in size.

摘要

使用酶联免疫吸附测定(ELISA)技术,在链脲佐菌素(STZ)诱导后的大鼠中,大约每隔一周测量一次神经生长因子(NGF)的水平。此外,在相同的每周间隔时间,测量通过向膀胱注射快蓝染料标记的L6-S1和L1-L2背根神经节神经元(DRG)的面积轮廓。与对照动物相比,NGF水平在一周时迅速上升至最大值,然后在接下来的三周内缓慢下降。DRG的面积增加到一个峰值,之后也开始下降。DRG面积轮廓的峰值增加相对于膀胱NGF的峰值水平有所延迟。数据表明,膀胱NGF逆向运输至DRG神经元,在那里它改变细胞代谢以导致细胞大小增加。

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