II型DNA拓扑异构酶
Type II DNA topoisomerases.
作者信息
Berger J M
机构信息
Whitehead Institute, Cambridge, MA 02142, USA.
出版信息
Curr Opin Struct Biol. 1998 Feb;8(1):26-32. doi: 10.1016/s0959-440x(98)80006-7.
PMID:9519293
Abstract
Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
摘要
II型DNA拓扑异构酶是能够使一条DNA双链穿过另一条的酶。结构分析与生化分析相结合，正在阐明这种转运反应的机制细节，揭示DNA和核苷酸结合位点以及大规模结构域运动的存在。
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