人中耳积液中血小板活化因子乙酰水解酶的存在。

The presence of platelet-activating factor-acetylhydrolase in human middle ear effusions.

作者信息

Tsuji H, Furukawa M, Ikeda H, Asako M, Yamashita T

机构信息

Department of Otolaryngology, Kansai Medical University, Osaka, Japan.

出版信息

ORL J Otorhinolaryngol Relat Spec. 1998 Jan-Feb;60(1):25-9. doi: 10.1159/000027558.

DOI:10.1159/000027558

PMID:9519378

Abstract

Factors related to inflammation, including platelet-activating factor (PAF), apparently have a role in chronic otitis media with effusion. PAF is metabolized to the biologically inactive lyso-PAF by the enzyme PAF-acetylhydrolase (PAF-AH). We have obtained evidence that PAF-AH activity is present in human middle ear effusions in patients with chronic otitis media with effusion. The present study revealed the enzyme in human middle ear effusions to be the plasma type PAF-AH. We suggest that PAF-AH may be involved in regulating inflammation in the middle ear by inactivating PAF, the potent proinflammatory autacoid.

摘要

与炎症相关的因素，包括血小板活化因子（PAF），显然在分泌性中耳炎中起作用。PAF被PAF-乙酰水解酶（PAF-AH）代谢为生物活性不高的溶血PAF。我们已获得证据表明，PAF-AH活性存在于分泌性中耳炎患者的人中耳积液中。本研究揭示人中耳积液中的该酶为血浆型PAF-AH。我们认为PAF-AH可能通过使强效促炎自分泌物质PAF失活而参与调节中耳炎症。