Kelman Z, Hurwitz J, O'Donnell M
Department of Molecular Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Structure. 1998 Feb 15;6(2):121-5. doi: 10.1016/s0969-2126(98)00014-8.
Replicative DNA polymerases are highly processive enzymes that polymerize thousands of nucleotides without dissociating from the DNA template. The recently determined structure of the Escherichia coli bacteriophage T7 DNA polymerase suggests a unique mechanism that underlies processivity, and this mechanism may generalize to other replicative polymerases.
复制性DNA聚合酶是高度持续合成的酶，能够聚合数千个核苷酸而不与DNA模板解离。最近确定的大肠杆菌噬菌体T7 DNA聚合酶的结构提示了一种构成持续合成能力基础的独特机制，并且这种机制可能适用于其他复制性聚合酶。
