Matschinsky F M, Glaser B, Magnuson M A
Department of Biochemistry and Biophysics and the Diabetes Research Center, University of Pennsylvania, Philadelphia 19104-6015, USA.
Diabetes. 1998 Mar;47(3):307-15. doi: 10.2337/diabetes.47.3.307.
There remains a wide gap between theoretical concepts and experimental realities in the enzyme kinetics and biochemical genetics of the pancreatic beta-cell glucokinase-glucose sensor. It is the goal of present efforts in many laboratories to bridge this gap. This perspective intends to provide a timely review of this crucial aspect of research in glucose homeostasis. It deals briefly with some fundamentals of glucokinase enzyme kinetics, offers some pertinent biochemical genetic considerations, takes stock of the current experimental database of the field by emphasizing human studies and referring to recent mouse studies, and ventures a few extrapolations into the future of this endeavor.
在胰腺β细胞葡萄糖激酶 - 葡萄糖传感器的酶动力学和生化遗传学方面，理论概念与实验现实之间仍然存在很大差距。弥合这一差距是许多实验室当前努力的目标。本观点旨在及时综述葡萄糖稳态研究这一关键方面。它简要论述了葡萄糖激酶酶动力学的一些基本原理，提出了一些相关的生化遗传学考量，通过强调人体研究并参考近期小鼠研究来评估该领域当前的实验数据库，并对这一研究的未来进行了一些推断。
