Argov Z
Department of Neurology, Hadassah University Hospital, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Eur Neurol. 1998;39(2):65-71. doi: 10.1159/000007912.
Most of the mitochondrial disorders affect the brain and muscle metabolism with variable degrees of impairment. The diagnostic usefulness of the following physiological and imaging methods, which also offer functional information that can be used for follow-up, is critically assessed: lactate levels, exercise testing, phosphorus magnetic resonance spectroscopy (MRS), proton MRS, functional magnetic resonance imaging, positron emission tomography, optical tissue oximetry and single photon emission tomography. Knowledge of the advantages, shortcomings and results of each method in the evaluation of mitochondrial diseases is mandatory before they can be applied to other disorders with suspected oxidative impairment.
大多数线粒体疾病会影响大脑和肌肉代谢，且损害程度各不相同。以下生理和成像方法的诊断效用，也能提供可用于随访的功能信息，现对此进行严格评估：乳酸水平、运动测试、磷磁共振波谱（MRS）、质子MRS、功能磁共振成像、正电子发射断层扫描、光学组织血氧测定法和单光子发射断层扫描。在将这些方法应用于其他疑似氧化损伤的疾病之前，必须了解每种方法在评估线粒体疾病中的优缺点及结果。
