大鼠丘脑底核的兴奋性毒性损伤可改善纹状体多巴胺耗竭诱导的不对称性。
Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat.
作者信息
Phillips J M, Latimer M P, Gupta S, Winn P, Brown V J
机构信息
School of Psychology, University of St. Andrews, Scotland, UK.
出版信息
Behav Brain Res. 1998 Jan;90(1):73-7. doi: 10.1016/s0166-4328(97)00080-6.
We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455-462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion. indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion.
我们使用一种躯体感觉不对称测试方法[T. Schallert等人，《药理学、生物化学与行为》16 (1982) 455 - 462]，研究了单侧背侧纹状体多巴胺耗竭（通过纹状体内注射6 - 羟基多巴胺）、丘脑底核（STN）的鹅膏蕈氨酸损伤以及多巴胺耗竭与STN损伤联合作用对感觉运动不对称性的影响。单侧纹状体多巴胺耗竭导致了躯体感觉不对称。在多巴胺耗竭与STN损伤联合的大鼠中，这种不对称性得到了改善。这表明在纹状体多巴胺耗竭的大鼠中，STN失活具有潜在的有益作用。
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