Shankle W R, Romney A K, Landing B H, Hara J
Department of Cognitive Science, University of California, Irvine, CA 92697-5100, USA.
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4023-8. doi: 10.1073/pnas.95.7.4023.
This paper uses correspondence analysis to examine the developmental patterns in the cytoarchitecture of the human cerebral cortex from birth to 72 months. The study is based on data collected by the late J. L. Conel, which consist of over 4 million individual measurements of six microscopic neuroanatomic features for each of six cortical layers in 46 cytoarchitecturally distinct regions. We analyze 1,727 profiles of development over eight age-points (term birth, 1, 3, 6, 15, 24, 48, and 72 postnatal months) resulting from the combinations of neuroanatomic feature, cortical layer, and brain cytoarchitectural region in the Conel data. The profiles for any given combination of feature and layer are found to be remarkably similar in all regions of the brain, and therefore the developmental patterns of different cytoarchitectural regions are not distinguishable from one another. Developmental change is most rapid at the earlier stages; of the total change in profile patterns observed, more than one-third occurs between birth and 6 months, about one-third occurs between 6 and 15 months, and less than one-third occurs between 15 and 72 months. The majority of the variance in developmental profiles is accounted for by the six microscopic, neuroanatomic features. Correspondence analysis shows that Conel's data are highly consistent and reliable.
本文运用对应分析方法，研究人类大脑皮质细胞结构从出生到72个月的发育模式。该研究基于已故的J. L. 科内尔收集的数据，这些数据包含对46个细胞结构不同区域的六个皮质层中每一层的六种微观神经解剖特征进行的400多万次个体测量。我们分析了来自科内尔数据中神经解剖特征、皮质层和脑细胞结构区域组合所产生的八个年龄点（足月出生、出生后1、3、6、15、24、48和72个月）的1727个发育概况。结果发现，在大脑的所有区域中，任何给定特征和层的组合所形成的概况都非常相似，因此不同细胞结构区域的发育模式无法相互区分。发育变化在早期最为迅速；在所观察到的概况模式的总体变化中，超过三分之一发生在出生到6个月之间，约三分之一发生在6到15个月之间，不到三分之一发生在15到72个月之间。发育概况中的大部分方差是由六种微观神经解剖特征造成的。对应分析表明，科内尔的数据高度一致且可靠。
