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本文引用的文献

1
Schistosoma mansoni: susceptibility differences between male and female mice can be mediated by testosterone during early infection.曼氏血吸虫：在早期感染期间，睾酮可介导雄性和雌性小鼠之间的易感性差异。
Exp Parasitol. 1997 Mar;85(3):233-40. doi: 10.1006/expr.1997.4148.
2
A review of dehydroepiandrosterone (DHEA).脱氢表雄酮（DHEA）综述。
Integr Physiol Behav Sci. 1995 Sep-Dec;30(4):308-13. doi: 10.1007/BF02691603.
3
Relationship between serum dehydroepiandrosterone sulfate, androstenedione, and sex hormones in men and women.男性和女性血清硫酸脱氢表雄酮、雄烯二酮与性激素之间的关系。
Eur J Endocrinol. 1996 Feb;134(2):201-6. doi: 10.1530/eje.0.1340201.
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Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection.
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5
Reversal of the immunosenescent phenotype by dehydroepiandrosterone: hormone treatment provides an adjuvant effect on the immunization of aged mice with recombinant hepatitis B surface antigen.脱氢表雄酮逆转免疫衰老表型：激素治疗对老年小鼠重组乙型肝炎表面抗原免疫接种具有佐剂作用。
J Infect Dis. 1993 Apr;167(4):830-40. doi: 10.1093/infdis/167.4.830.
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Failure of schistosomiasis to significantly decrease testosterone levels in Brazilian men.
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Physiological importance of dehydroepiandrosterone.脱氢表雄酮的生理重要性。
Lancet. 1994 Jun 11;343(8911):1479-81. doi: 10.1016/s0140-6736(94)92587-9.
8
Effects of dehydroepiandrosterone in immunosuppressed adult mice infected with Cryptosporidium parvum.脱氢表雄酮对感染微小隐孢子虫的免疫抑制成年小鼠的影响。
J Parasitol. 1995 Jun;81(3):429-33.
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Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood.
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Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA).
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硫酸脱氢表雄酮对小鼠的治疗可调节曼氏血吸虫感染。

Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni.

作者信息

Fallon P G, Richardson E J, Jones F M, Dunne D W

机构信息

Department of Pathology, University of Cambridge, United Kingdom.

出版信息

Clin Diagn Lab Immunol. 1998 Mar;5(2):251-3. doi: 10.1128/CDLI.5.2.251-253.1998.

DOI:10.1128/CDLI.5.2.251-253.1998
PMID:9521152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC121367/
Abstract

Female mice treated with dehydroepiandrosterone sulfate early during infection were partially protected (P < 0.05-0.005) from Schistosoma mansoni infection. Hormone treatment did not modify parasite-specific cellular or humoral responses. Serum dehydroepiandrosterone sulfate levels and testosterone infection were negatively correlated, r = -0.621 and r = -0.653, respectively, with schistosome worm burden. The partial resistance to schistosome infection in dehydroepiandrosterone sulfate-treated female mice may be due to the known antischistosomular activity of testosterone.

摘要

在感染早期用硫酸脱氢表雄酮处理的雌性小鼠对曼氏血吸虫感染有部分保护作用（P < 0.05 - 0.005）。激素处理并未改变寄生虫特异性细胞或体液反应。血清硫酸脱氢表雄酮水平和睾酮感染与血吸虫虫负荷呈负相关，r分别为 -0.621和 -0.653。硫酸脱氢表雄酮处理的雌性小鼠对血吸虫感染的部分抗性可能归因于睾酮已知的抗血吸虫活性。