硫酸脱氢表雄酮对小鼠的治疗可调节曼氏血吸虫感染。
Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni.
作者信息
Fallon P G, Richardson E J, Jones F M, Dunne D W
机构信息
Department of Pathology, University of Cambridge, United Kingdom.
出版信息
Clin Diagn Lab Immunol. 1998 Mar;5(2):251-3. doi: 10.1128/CDLI.5.2.251-253.1998.
Abstract
Female mice treated with dehydroepiandrosterone sulfate early during infection were partially protected (P < 0.05-0.005) from Schistosoma mansoni infection. Hormone treatment did not modify parasite-specific cellular or humoral responses. Serum dehydroepiandrosterone sulfate levels and testosterone infection were negatively correlated, r = -0.621 and r = -0.653, respectively, with schistosome worm burden. The partial resistance to schistosome infection in dehydroepiandrosterone sulfate-treated female mice may be due to the known antischistosomular activity of testosterone.
摘要
在感染早期用硫酸脱氢表雄酮处理的雌性小鼠对曼氏血吸虫感染有部分保护作用（P < 0.05 - 0.005）。激素处理并未改变寄生虫特异性细胞或体液反应。血清硫酸脱氢表雄酮水平和睾酮感染与血吸虫虫负荷呈负相关，r分别为 -0.621和 -0.653。硫酸脱氢表雄酮处理的雌性小鼠对血吸虫感染的部分抗性可能归因于睾酮已知的抗血吸虫活性。
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