Kohut M L, Davis J M, Jackson D A, Colbert L H, Strasner A, Essig D A, Pate R R, Ghaffar A, Mayer E P
Department of Exercise Science, School of Public Health, University of South Carolina, Columbia 29208, USA.
J Neuroimmunol. 1998 Jan;81(1-2):193-200. doi: 10.1016/s0165-5728(97)00179-3.
We hypothesized that a previously observed exercise-induced suppression of alveolar macrophage antiviral resistance results from increases in corticosterone and/or epinephrine. Mice (CD-1) were run to fatigue on a treadmill (exercise), or placed in Plexiglas lanes above the treadmill (control). The role of corticosterone was assessed by further dividing mice into groups receiving one of the following treatments; sham surgery, adrenalectomy, or adrenalectomy plus corticosterone replacement. Macrophage antiviral function was suppressed in the exercised mice compared to the control mice. However, macrophage antiviral function was not suppressed in the exercised mice that underwent adrenalectomy or adrenalectomy plus corticosterone replacement. We tested whether another adrenal factor (epinephrine) may be involved by dividing mice into exercise and control groups treated with either saline or propranolol. Macrophage antiviral function was again suppressed in the saline-treated exercised mice compared to saline-treated control mice, but no differences were found between the exercised mice receiving propranolol, control mice receiving propranolol, or saline-treated control mice. Isoproterenol, when added to alveolar macrophages in culture, also suppressed antiviral resistance. These findings suggest that decreased macrophage antiviral function following exercise may be due to increased release of adrenal catecholamines.
我们推测，先前观察到的运动诱导的肺泡巨噬细胞抗病毒抗性抑制是由皮质酮和/或肾上腺素增加所致。将小鼠（CD - 1）置于跑步机上使其运动至疲劳（运动组），或将其置于跑步机上方的有机玻璃通道中（对照组）。通过将小鼠进一步分为接受以下治疗之一的组来评估皮质酮的作用：假手术、肾上腺切除术或肾上腺切除术加皮质酮替代。与对照小鼠相比，运动小鼠的巨噬细胞抗病毒功能受到抑制。然而，接受肾上腺切除术或肾上腺切除术加皮质酮替代的运动小鼠的巨噬细胞抗病毒功能并未受到抑制。我们通过将小鼠分为用生理盐水或普萘洛尔处理的运动组和对照组，来测试是否可能涉及另一种肾上腺因子（肾上腺素）。与用生理盐水处理的对照小鼠相比，用生理盐水处理的运动小鼠的巨噬细胞抗病毒功能再次受到抑制，但接受普萘洛尔的运动小鼠、接受普萘洛尔的对照小鼠或用生理盐水处理的对照小鼠之间未发现差异。在培养的肺泡巨噬细胞中加入异丙肾上腺素也会抑制抗病毒抗性。这些发现表明，运动后巨噬细胞抗病毒功能的降低可能是由于肾上腺儿茶酚胺释放增加所致。
