Xue F S, Liao X, Tong S Y, An G, Luo L K
Department of Anaesthesia, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Eur J Anaesthesiol. 1998 Jan;15(1):21-6. doi: 10.1046/j.1365-2346.1998.00224.x.
The influence of acute moderate haemodilution on the relation between dose and response for rocuronium was evaluated in 60 adult patients, ASA grade I, undergoing elective plastic surgery. The patients were randomly allocated to either the control or the haemodilution group. Following the induction of general anaesthesia, the status of acute moderate haemodilution in the haemodilution group was achieved by draining venous blood, and intravenous infusion of lactated Ringer's solution, 6% dextran or gelofusine, during which the levels of haemoatocrit and haemoglobin dropped from 44% to 27.5% and from 148.3 to 91.3 g L-1, respectively. Neuromuscular function was assessed mechanomyographically with train-of-four stimulation at the wrist every 12 s and the percentage depression of T1 response was used as the study parameter. The relation between dose and response for rocuronium in the two groups was determined by the cumulative dose-response technique. The results showed that the dose-response curve for rocuronium during acute moderate haemodilution was shifted in a parallel fashion to the left and the potency of rocuronium was increased. There were significant differences in ED50, ED90 and ED95 between the two groups. The ED50, ED90 and ED95 of rocuronium in the haemodilution group was decreased by 28.2%, 35.4% and 38.8%, respectively, compared with the control group.
在60例接受择期整形手术的美国麻醉医师协会（ASA）I级成年患者中，评估了急性中度血液稀释对罗库溴铵剂量-反应关系的影响。患者被随机分为对照组或血液稀释组。全身麻醉诱导后，血液稀释组通过抽取静脉血并静脉输注乳酸林格氏液、6%右旋糖酐或琥珀明胶来实现急性中度血液稀释状态，在此期间，血细胞比容水平从44%降至27.5%，血红蛋白水平从148.3 g/L降至91.3 g/L。每隔12秒在手腕处用四个成串刺激通过肌机械图评估神经肌肉功能，T1反应的抑制百分比用作研究参数。采用累积剂量-反应技术确定两组中罗库溴铵的剂量-反应关系。结果表明，急性中度血液稀释期间罗库溴铵的剂量-反应曲线平行向左移动，罗库溴铵的效能增加。两组之间的半数有效剂量（ED50）、90%有效剂量（ED90）和95%有效剂量（ED95）存在显著差异。与对照组相比，血液稀释组中罗库溴铵的ED50、ED90和ED95分别降低了28.2%、35.4%和38.8%。
