Larson B, Collins A, Landgren B M
Department of Woman and Child Health, Karolinska Hospital, Stockholm, Sweden.
Maturitas. 1997 Dec 15;28(2):99-105. doi: 10.1016/s0378-5122(97)00068-6.
To investigate the relationship between climacteric status, hormonal levels, vasomotor symptoms, vaginal dryness and urinary incontinence in a cohort of healthy women during transition to menopause, and further to evaluate the effects of hormone replacement therapy on these symptoms.
A total of 147 women were followed for 4 years during transition to menopause. They were all 49 years old when entering the study. Each annual visit included a general health screening, gynecological examination and blood sampling. The subjects were questioned about sociodemographic background, obstetric and gynecological history and they kept bleeding diary cards.
Urinary incontinence was reported by 57% at the first visit and decreased to 34% at the last visit. No correlation to hormonal levels or to the use of HRT (hormone replacement therapy) was seen, but parity was significantly (P = 0.05) correlated to urinary incontinence. Vaginal dryness occurred in 37% at the first visit. Vaginal dryness was experienced by 1/3 of the premenopausal women. Vasomotor symptoms were reported by 56% at the first visit and were associated with high levels of FSH and LH (P < 0.001 and P = 0.002, respectively). One third of premenopausal women reported on vasomotor symptoms. Hormone replacement therapy did not relieve hot flushes in these women.
Urogenital and vasomotor symptoms experienced by premenopausal women do not seem to be relieved by hormone replacement therapy.
调查一群处于围绝经期过渡阶段的健康女性的更年期状态、激素水平、血管舒缩症状、阴道干涩和尿失禁之间的关系，并进一步评估激素替代疗法对这些症状的影响。
共有147名女性在围绝经期过渡阶段被随访4年。她们进入研究时均为49岁。每次年度随访包括全面健康筛查、妇科检查和血液采样。对受试者询问社会人口统计学背景、妇产科病史，并让她们记录出血日记卡。
首次就诊时57%的人报告有尿失禁，最后一次就诊时降至34%。未发现与激素水平或激素替代疗法（HRT）的使用有相关性，但产次与尿失禁有显著相关性（P = 0.05）。首次就诊时37%的人出现阴道干涩。三分之一的绝经前女性有阴道干涩症状。首次就诊时56%的人报告有血管舒缩症状，且与高水平的促卵泡生成素（FSH）和促黄体生成素（LH）相关（分别为P < 0.001和P = 0.002）。三分之一的绝经前女性报告有血管舒缩症状。激素替代疗法未能缓解这些女性的潮热症状。
绝经前女性经历的泌尿生殖系统和血管舒缩症状似乎无法通过激素替代疗法得到缓解。
