Hurwitz A L, Duranceau A, Postlethwait R W
Am J Dig Dis. 1976 Aug;21(8):601-6. doi: 10.1007/BF01071951.
The relationship of Raynaud's phenomenon (RP) to the degree of esophageal motility dysfunction was evaluated in 12 patients with scleroderma. Motility abnormalities of the smooth muscle esophagus were quantitated using a motility index (MI). MI of the scleroderma patients differed significantly from controls. No relationship was noted between the extent of motility abnormality and the duration or severity of the RP. A nearly uniform finding was the absence of coordinated esophageal peristalsis, occurring regardless of the duration or severity of the RP. The study demonstrates that it is not possible to predict the degree of esophageal motility dysfunction in scleroderma based on RP alone. The disease may have two different and independent pathogenetic components. One component is closely linked to RP and involves impairment of neuromuscular electrical transmission. The other component (independent of RP) involves progressive loss of muscle strength in the distal esophagus and in the lower esophageal sphincter.
对12例硬皮病患者评估雷诺现象（RP）与食管动力功能障碍程度的关系。使用动力指数（MI）对食管平滑肌的动力异常进行定量分析。硬皮病患者的MI与对照组有显著差异。未发现动力异常程度与RP的病程或严重程度之间存在相关性。几乎一致的发现是无论RP的病程或严重程度如何，均无协调性食管蠕动。该研究表明，仅根据RP无法预测硬皮病患者食管动力功能障碍的程度。该病可能有两个不同且独立的致病因素。一个因素与RP密切相关，涉及神经肌肉电传导受损。另一个因素（与RP无关）涉及食管远端和食管下括约肌肌肉力量的逐渐丧失。
