Murzenok P P, Netukova N I, Zhytkevitch T I
Department of Applied Physiology, National Academy of Sciences, Mińsk, Republic of Belarus.
Arch Immunol Ther Exp (Warsz). 1997;45(4):301-5.
The ultrastructure and proliferative activity of lymphoid tissue cells in rabbits after repeated exposures to lipopolysaccharide (LPS) or external heating were studied. It was shown that in conditions of the same increase in body temperature the production of IL-1-like activity by blood and splenic cells was inhibited to the same extent in both groups of animals. It was suggested that one of the causes of LPS-induced tolerance may be events provoked by temperature factor per se. There were similar changes in activity of epithelial cells in the thymus, reticular cells in the spleen, in activation of mast cells in these organs and in proliferative processes in the thymus after both exposures, however inhibition of proliferative activity of splenic and lymph node cells was observed only in LPS-treated animals.
研究了家兔反复暴露于脂多糖（LPS）或外部加热后淋巴组织细胞的超微结构和增殖活性。结果表明，在两组动物体温同样升高的情况下，血液和脾细胞产生IL-1样活性均受到同等程度的抑制。有人提出，LPS诱导耐受性的原因之一可能是温度因素本身引发的事件。两种暴露后，胸腺上皮细胞活性、脾中网状细胞、这些器官中肥大细胞的活化以及胸腺中的增殖过程都有类似变化，然而仅在LPS处理的动物中观察到脾细胞和淋巴结细胞增殖活性受到抑制。
