Murzenok P P, Netukova N I
Department of Applied Physiology, Institute of Physiology of Academy of Sciences, Minsk, Republic of Belarus.
Arch Immunol Ther Exp (Warsz). 1994;42(4):301-5.
The structural and functional organization of the rabbit immunocompetent cells after injection of human recombinant interleukin 1 beta (IL-1 beta), partially purified leukocytic pyrogen (LP), or after external heating (36 degrees C, 1.5 h) was compared. A rectal temperature increase being the same, there were similar and transient changes in epithelial and endothelial cells and macrophages, a rise in the proliferative activity of thymocytes and synthesis of IL-1-like activity, and a decrease in the interleukin 2 (IL-2) production by cultured splenic cells.
对注射人重组白细胞介素1β（IL-1β）、部分纯化的白细胞热原（LP）后或外部加热（36℃，1.5小时）的兔免疫活性细胞的结构和功能组织进行了比较。在直肠温度升高相同的情况下，上皮细胞、内皮细胞和巨噬细胞出现相似的短暂变化，胸腺细胞的增殖活性升高以及IL-1样活性的合成增加，并且培养的脾细胞产生的白细胞介素2（IL-2）减少。
