Glass J M, Bdesha A S, Witherow R O
Department of Urology, St Mary's Hospital, London, UK.
Br J Urol. 1998 Mar;81(3):377-82. doi: 10.1046/j.1464-410x.1998.00559.x.
To determine the long-term therapeutic value of transurethral microwave thermotherapy (TUMT) in the treatment of bladder outflow obstruction secondary to benign prostatic hyperplasia (BPH).
A total of 67 patients with BPH, assessed using symptom scores and measurements of urinary flow rate, underwent TUMT using the Leo Microthermer system (Laser Electro Optics Ltd, London, UK) between October 1990 and June 1992. Follow-up information was obtained on 60 patients (90%). If they had undergone no further treatment for their BPH, they were re-assessed with symptom scores and measurements of flow rate.
The mean follow-up was 52.4 months; eight of the 6 7 patients had died and seven were lost to follow-up. Sixteen of the remaining 52 (31%) had undergone another treatment for BPH; one patient developed prostatitis and one developed localized carcinoma of the prostate. Thirty-four patients had had no further treatment, 29 of whom attended for assessment. In these patients, a statistically significant improvement in both the symptom score and flow rate was maintained at 4 years. No patients developed retrograde ejaculation.
This is the first study to report a follow-up of at least 4 years after TUMT with any device. Treatment with the Leo Microthermer provided at least a 50% symptomatic improvement in 16 of 50 patients treated at 4 years. However, 30% of the patients needed further treatment for their BPH. TUMT is safe and effective in patients not wanting anaesthesia and in young patients concerned about retrograde ejaculation.
确定经尿道微波热疗(TUMT)治疗良性前列腺增生(BPH)继发膀胱出口梗阻的长期治疗价值。
1990年10月至1992年6月期间,共有67例BPH患者接受症状评分和尿流率测量评估,并使用Leo Microthermer系统(英国伦敦激光电光有限公司)进行TUMT。60例患者(90%)获得随访信息。若他们未因BPH接受进一步治疗,则再次进行症状评分和尿流率测量评估。
平均随访时间为52.4个月;67例患者中有8例死亡,7例失访。其余52例患者中,16例(31%)因BPH接受了另一种治疗;1例患者发生前列腺炎,1例发生局限性前列腺癌。34例患者未接受进一步治疗,其中29例前来接受评估。在这些患者中,症状评分和尿流率在4年时均保持有统计学意义的改善。无患者发生逆行射精。
这是第一项报告使用任何设备进行TUMT后至少4年随访情况的研究。使用Leo Microthermer治疗,在4年时接受治疗的50例患者中有16例症状改善至少50%。然而,30%的患者因BPH需要进一步治疗。TUMT对于不希望接受麻醉的患者以及担心逆行射精的年轻患者而言是安全有效的。