Odderson I R
Department of Rehabilitation Medicine, University of Washington, Seattle, USA.
Arch Phys Med Rehabil. 1998 Mar;79(3):350-2. doi: 10.1016/s0003-9993(98)90020-x.
Hyperhidrosis can be emotionally challenging and socially and professionally disruptive, and there are few effective treatments. This condition was successfully treated with botulinum toxin in two men who, since their early teens, had had excessive axillary sweating, requiring frequent shirt changes. They received bilateral axillary injections with 100 units of botulinum toxin type A, and within 5 days reported cessation of excessive sweating. Quantitative measurements before and 2 to 4 weeks after the injections demonstrated an average reduction of 71% and 76% (from 11.6 to 3.4 and from 2.5 to 0.6 mL/min m2) in axillary sweating during rest. A 96% reduction (from 42.9 to 1.7 mL/min m2) was seen in one patient during mental stress. No complications developed. This study quantitates the reduced axillary sweating achieved through chemodenervation with botulinum toxin A.
多汗症在情绪上可能具有挑战性，在社交和职业方面也会造成干扰，而且有效的治疗方法很少。两名男性自青少年早期就患有腋下多汗症，需要频繁更换衬衫，肉毒杆菌毒素成功治愈了他们的这种疾病。他们双侧腋下注射了100单位的A型肉毒杆菌毒素，5天内报告称多汗症状停止。注射前以及注射后2至4周的定量测量显示，静息时腋下出汗平均减少了71%和76%（从11.6降至3.4以及从2.5降至0.6 mL/min m2）。一名患者在精神压力下出汗减少了96%（从42.9降至1.7 mL/min m2）。未出现并发症。本研究对通过A型肉毒杆菌毒素化学去神经支配实现的腋下出汗减少进行了量化。
