Gargiulo P A, Siemann M, Delius J D
Laboratorio de Neurociencias y Psicología Experimental, Universidad Católica de Mendoza, Argentina.
Physiol Behav. 1998 Feb 15;63(4):705-9. doi: 10.1016/s0031-9384(97)00516-7.
The nucleus accumbens septi (Acc) is thought to be involved in the control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of pigeons.
伏隔核（Acc）被认为参与认知过程的控制，并与精神分裂症的病理生理学有关。由于感知认知扭曲是精神分裂症的核心症状，任何关于伏隔核在动物物种的感官识别任务中发挥作用的证据都将是有意义的。对鸽子进行操作性训练以辨别视觉形状。研究了向伏隔核微量注射药物对训练形状辨别、错误后的纠正反应以及对不同形状的泛化的急性影响。测试了利多卡因传导阻滞、7-氨基膦庚酸谷氨酸能阻滞和阿扑吗啡多巴胺能刺激对行为表现的影响。利多卡因和阿扑吗啡未观察到影响。向伏隔核注射氨基膦庚酸后，获得了显著且可逆的性能破坏，接近随机水平。似乎伏隔核的谷氨酸能阻滞会干扰鸽子的视觉辨别过程。
