Jacobs G, Calvert C, Kaufman A
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
J Am Vet Med Assoc. 1998 Mar 1;212(5):681-4.
Three dogs became lethargic and had poor appetites within 2 months after anticonvulsant treatment was initiated to control seizures. Dogs were neutropenic, thrombocytopenic, and anemic and had splenomegaly. Sensitivity to phenobarbital and related anticonvulsants may induce life-threatening leukopenia, thrombocytopenia, and anemia in dogs. Phenobarbital-induced neutropenia in these 3 dogs may have posed a risk for developing bacteremia. It is important for clinicians to be aware of adverse effects so that adequate precautions can be taken. A baseline hemogram should always be obtained before starting anticonvulsant treatment, and periodic hemograms should be obtained to monitor animals. Furthermore, client education should include instructions on recognizing signs of bacteremia, thrombocytopenia, and anemia.
在开始使用抗惊厥药物治疗以控制癫痫发作后的2个月内，3只狗变得嗜睡且食欲不佳。这些狗出现了中性粒细胞减少、血小板减少和贫血，并且脾脏肿大。对苯巴比妥及相关抗惊厥药物的敏感性可能会在狗身上诱发危及生命的白细胞减少、血小板减少和贫血。这3只狗因苯巴比妥诱导的中性粒细胞减少可能存在发生菌血症的风险。临床医生了解不良反应很重要，以便采取充分的预防措施。在开始抗惊厥治疗前应始终获取基线血常规，并且应定期获取血常规以监测动物。此外，对客户的教育应包括识别菌血症、血小板减少和贫血体征的指导。
