Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
Can Vet J. 2021 Dec;62(12):1341-1343.
A 4-year-old neutered male St. Bernard-mastiff crossbred dog showed clinical signs of lethargy and anorexia after being administered phenobarbital for the treatment of idiosyncratic seizures. A complete blood (cell) count revealed pancytopenia. Auto-agglutination and Coombs tests were negative suggesting that an immunemediated cause was unlikely; therefore, an idiosyncratic reaction to phenobarbital was suspected. Supportive care and control of seizures with zonisamide was initiated and clinical signs improved. Blood values were monitored closely and returned to normal after 3 wk.
一只 4 岁已去势的雄性圣伯纳-獒混血犬，在接受苯巴比妥治疗特发性癫痫后出现嗜睡和食欲不振的临床症状。全血细胞计数显示全血细胞减少。自身凝集和抗球蛋白试验均为阴性，提示免疫介导的可能性不大；因此，疑似对苯巴比妥产生的特发性反应。开始使用左乙拉西坦进行支持性治疗和控制癫痫发作，临床症状得到改善。密切监测血液值，3 周后恢复正常。
