Bhatti Sofie F M, De Risio Luisa, Muñana Karen, Penderis Jacques, Stein Veronika M, Tipold Andrea, Berendt Mette, Farquhar Robyn G, Fischer Andrea, Long Sam, Löscher Wolfgang, Mandigers Paul J J, Matiasek Kaspar, Pakozdy Akos, Patterson Edward E, Platt Simon, Podell Michael, Potschka Heidrun, Rusbridge Clare, Volk Holger A
Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium.
Animal Health Trust, Lanwades Park, Kentford, Newmarket, CB8 7UU, Suffolk, United Kingdom.
BMC Vet Res. 2015 Aug 28;11:176. doi: 10.1186/s12917-015-0464-z.
In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years. Nevertheless, the same questions remain, which include, 1) when to start treatment, 2) which drug is best used initially, 3) which adjunctive AED can be advised if treatment with the initial drug is unsatisfactory, and 4) when treatment changes should be considered. In this consensus proposal, an overview is given on the aim of AED treatment, when to start long-term treatment in canine epilepsy and which veterinary AEDs are currently in use for dogs. The consensus proposal for drug treatment protocols, 1) is based on current published evidence-based literature, 2) considers the current legal framework of the cascade regulation for the prescription of veterinary drugs in Europe, and 3) reflects the authors' experience. With this paper it is aimed to provide a consensus for the management of canine idiopathic epilepsy. Furthermore, for the management of structural epilepsy AEDs are inevitable in addition to treating the underlying cause, if possible.
在欧洲,过去几年中已获许可用于犬类的抗癫痫药物(AEDs)数量大幅增加。然而,同样的问题依然存在,其中包括:1)何时开始治疗;2)最初最好使用哪种药物;3)如果初始药物治疗效果不佳,可推荐哪种辅助抗癫痫药物;4)何时应考虑改变治疗方案。在本共识建议中,概述了抗癫痫药物治疗的目的、何时开始犬癫痫的长期治疗以及目前哪些兽用抗癫痫药物用于犬类。药物治疗方案的共识建议:1)基于当前已发表的循证文献;2)考虑欧洲兽药处方分级管理制度的现行法律框架;3)反映作者的经验。本文旨在为犬特发性癫痫的管理提供共识。此外,对于结构性癫痫的管理,除了尽可能治疗潜在病因外,抗癫痫药物也是必不可少的。