Lavenu I, Pasquier F, Lebert F, Pruvo J P, Petit H
Department of Neurology, University Hospital of Lille, France.
Dement Geriatr Cogn Disord. 1998 Mar-Apr;9(2):99-102. doi: 10.1159/000017030.
In our memory clinic experience, memory impairment differs widely in patients with frontotemporal dementia (FTD). We searched for a correlation between explicit memory disturbance assessed with the Grober and Buschke test and medial temporal atrophy on CT scan in 22 consecutive patients with FTD. Five of the 22 patients had a medial temporal lobe (MTL) atrophy. There was no significant difference between the two groups for the demographic characteristics. Free recall, cued recall and the learning curve were significantly better in patients without MTL atrophy. The patients with MTL atrophy made more intrusions. We found a positive correlation between total recall and cued recall and the mean of medial temporal lobe measurement. These results are in agreement with the role of the hippocampal formation in the memory process. In our group, the ratio of patients with MTL atrophy is similar to the ratio of Pick's disease in frontotemporal dementia. In histological series more severe hippocampal atrophy are reported in Pick's disease. Therefore MTL atrophy on CT scan could be a marker of Pick's disease in FTD.
在我们记忆门诊的经验中，额颞叶痴呆（FTD）患者的记忆损害差异很大。我们在22例连续的FTD患者中，探寻用格罗贝尔和布施克测试评估的外显记忆障碍与CT扫描显示的内侧颞叶萎缩之间的相关性。22例患者中有5例存在内侧颞叶（MTL）萎缩。两组在人口统计学特征方面无显著差异。无MTL萎缩的患者在自由回忆、线索回忆和学习曲线上表现明显更好。MTL萎缩的患者出现更多的错误记忆。我们发现总回忆和线索回忆与内侧颞叶测量平均值之间存在正相关。这些结果与海马结构在记忆过程中的作用相符。在我们的研究组中，MTL萎缩患者的比例与额颞叶痴呆中皮克病患者的比例相似。在组织学系列研究中，皮克病报告有更严重的海马萎缩。因此，CT扫描显示的MTL萎缩可能是FTD中皮克病的一个标志物。
