Husni R N, Gordon S M, Longworth D L, Arroliga A, Stillwell P C, Avery R K, Maurer J R, Mehta A, Kirby T
Department of Infectious Diseases, Cleveland Clinic Foundation, Ohio 44195, USA.
Clin Infect Dis. 1998 Mar;26(3):753-5. doi: 10.1086/514599.
Invasive aspergillosis (IA) remains a major cause of morbidity and mortality following solid organ transplantation. To assess the incidence of IA following lung transplantation and to identify risk factors for its occurrence, we performed a case-control study involving 101 patients undergoing lung transplantation at our institution from 1990 to 1995 and reviewed the findings. Fourteen patients (14%) developed IA. The mean time from transplantation to diagnosis was 15 months. Nine patients died; the mean time to death from diagnosis was 13 days. Risk factors associated with developing IA included concomitant cytomegalovirus (CMV) pneumonia or viremia and culture isolation of Aspergillus species from a respiratory tract specimen after lung transplantation. Optimal strategies to prevent IA in lung transplant recipients remain to be determined, but prevention of aspergillus airway colonization and CMV viremia and disease after transplantation may be important targets for prophylactic interventions.
侵袭性曲霉病（IA）仍然是实体器官移植后发病和死亡的主要原因。为了评估肺移植后IA的发病率并确定其发生的危险因素，我们进行了一项病例对照研究，纳入了1990年至1995年在我们机构接受肺移植的101例患者，并对研究结果进行了回顾。14例患者（14%）发生了IA。从移植到诊断的平均时间为15个月。9例患者死亡；从诊断到死亡的平均时间为13天。与发生IA相关的危险因素包括合并巨细胞病毒（CMV）肺炎或病毒血症以及肺移植后呼吸道标本中曲霉菌属的培养分离。预防肺移植受者IA的最佳策略仍有待确定，但预防移植后曲霉菌气道定植以及CMV病毒血症和疾病可能是预防性干预的重要目标。
