Dujardin K, Guieu J D, Leconte-Lambert C, Leconte P, Borderies P, de La Giclais B
Labacolil, Lille III University, Villeneuve, France.
Pharmacopsychiatry. 1998 Jan;31(1):14-8. doi: 10.1055/s-2007-979289.
The effects of zolpidem 10 mg, flunitrazepam 1 mg, and placebo, administrated at bedtime, were studied in 12 healthy male insomniac patients. The assessments included polygraphic sleep recordings during the night and a battery of cognitive tests (sign crossing test, dichotic listening test, digit span test, visual recognition test and free recall test during four times during the following day. Compared with placebo, both active drugs improved sleep parameters. However, with zolpidem, the results were not statistically different from placebo. Zolpidem dit not alter sleep architecture in contrast to flunitrazepam, which significantly increased stage 2 and decreased slow wave sleep and REM sleep. No significant interaction was found between time of day for the evaluation of cognitive function. Flunitrazepam significantly impaired attention and memory compared with zolpidem and placebo, while zolpidem did not differ from placebo. These results indicate that zolpidem 10 mg preserved sleep structure and daytime cognitive functions in contrast to flunitrazepam.
对12名健康男性失眠患者研究了睡前服用10毫克唑吡坦、1毫克氟硝西泮和安慰剂的效果。评估包括夜间多导睡眠记录以及一系列认知测试（符号交叉测试、双耳分听测试、数字广度测试、视觉识别测试以及在接下来的一天中进行四次自由回忆测试）。与安慰剂相比，两种活性药物均改善了睡眠参数。然而，唑吡坦的结果与安慰剂无统计学差异。与氟硝西泮不同，唑吡坦未改变睡眠结构，氟硝西泮显著增加了2期睡眠，减少了慢波睡眠和快速眼动睡眠。在评估认知功能的时间方面未发现显著相互作用。与唑吡坦和安慰剂相比，氟硝西泮显著损害注意力和记忆力，而唑吡坦与安慰剂无差异。这些结果表明，与氟硝西泮相比，10毫克唑吡坦可保留睡眠结构和白天的认知功能。
