来自兄弟叶下珠的链状酰胺类化合物。
Alkamides from Phyllanthus fraternus.
作者信息
Sittie A A, Lemmich E, Olsen C E, Hviid L, Brøgger Christensen S
出版信息
Planta Med. 1998 Mar;64(2):192-3. doi: 10.1055/s-2006-957405.
PMID:9525113
Abstract
Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.
摘要
两种链状酰胺，即E,E-2,4-辛二烯酰胺和E,Z-2,4-癸二烯酰胺，已从叶下珠中分离出来，叶下珠是一种在加纳传统医学中用于治疗疟疾的植物。这些化合物具有α,β,γ,δ-不饱和共轭酰胺，这一特征被认为可增强抗疟活性。通过体外试验表明，这两种链状酰胺具有中等抗疟活性。
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