Oketch-Rabah H A, Brøgger Christensen S, Frydenvang K, Dossaji S F, Theander T G, Cornett C, Watkins W M, Kharazmi A, Lemmich E
Phytochemistry Department, National Museums of Kenya, Nairobi.
Planta Med. 1998 Aug;64(6):559-62. doi: 10.1055/s-2006-957514.
Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. An X-ray crystallographic analysis established the absolute configuration and some signals in the NMR spectra were reassigned. 16,17-Dihydrobrachycalyxolide (1) elicited a strong antiplasmodial and antileishmanial activity but also a high toxicity against human lymphocytes.
短萼斑鸠菊叶片提取物显示出对恶性疟原虫和硕大利什曼原虫前鞭毛体的体外活性。先前从该植物地上部分分离得到的吉马烷双内酯16,17 - 二氢短萼斑鸠菊内酯（1）被证明是主要的抗疟成分。X射线晶体学分析确定了其绝对构型，并重新归属了核磁共振谱中的一些信号。16,17 - 二氢短萼斑鸠菊内酯（1）具有很强的抗疟和抗利什曼原虫活性，但对人淋巴细胞也有很高的毒性。
