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本文引用的文献

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Development of an alloantiserum (R2) that detects susceptibility of chickens to subgroup E endogenous avian leukosis virus.
Avian Pathol. 1996 Sep;25(3):551-68. doi: 10.1080/03079459608419161.
2
Identification of a cellular receptor for subgroup E avian leukosis virus.E亚群禽白血病病毒细胞受体的鉴定
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11617-22. doi: 10.1073/pnas.94.21.11617.
3
CAR1, a TNFR-related protein, is a cellular receptor for cytopathic avian leukosis-sarcoma viruses and mediates apoptosis.CAR1是一种与肿瘤坏死因子受体相关的蛋白质，是细胞病变性禽白血病-肉瘤病毒的细胞受体，并介导细胞凋亡。
Cell. 1996 Nov 29;87(5):845-55. doi: 10.1016/s0092-8674(00)81992-3.
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RFLP mapping of expressed sequence tags in the chicken.鸡中表达序列标签的限制性片段长度多态性图谱分析
J Hered. 1996 Jan-Feb;87(1):6-9. doi: 10.1093/oxfordjournals.jhered.a022954.
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Mapping functional chicken genes: an alternative approach.
Poult Sci. 1996 May;75(5):642-7. doi: 10.3382/ps.0750642.
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An autosomal genetic linkage map of the chicken.鸡的常染色体遗传连锁图谱。
J Hered. 1994 Mar-Apr;85(2):79-85. doi: 10.1093/oxfordjournals.jhered.a111427.
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"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.一种将DNA限制性内切酶片段放射性标记至高比活度的技术。附录
Anal Biochem. 1984 Feb;137(1):266-7. doi: 10.1016/0003-2697(84)90381-6.
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Genomic sequencing.基因组测序
Proc Natl Acad Sci U S A. 1984 Apr;81(7):1991-5. doi: 10.1073/pnas.81.7.1991.
9
Cell killing by avian leukosis viruses.禽白血病病毒引起的细胞杀伤
J Virol. 1981 Sep;39(3):713-21. doi: 10.1128/JVI.39.3.713-721.1981.
10
Correlation between cell killing and massive second-round superinfection by members of some subgroups of avian leukosis virus.禽白血病病毒某些亚群成员的细胞杀伤与大规模第二轮超级感染之间的相关性。
J Virol. 1980 Jan;33(1):494-506. doi: 10.1128/JVI.33.1.494-506.1980.

编码B亚群和D亚群禽白血病病毒特异性细胞受体的CAR1基因定位于鸡的tvb基因座。

The CAR1 gene encoding a cellular receptor specific for subgroup B and D avian leukosis viruses maps to the chicken tvb locus.

作者信息

Smith E J, Brojatsch J, Naughton J, Young J A

机构信息

Avian Disease and Oncology Laboratory, Agricultural Research Service, USDA, East Lansing, Michigan 48823, USA.

出版信息

J Virol. 1998 Apr;72(4):3501-3. doi: 10.1128/JVI.72.4.3501-3503.1998.

DOI:10.1128/JVI.72.4.3501-3503.1998
PMID:9525691
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC109869/
Abstract

Host susceptibility to subgroup B, D, and E avian leukosis viruses (ALV) is determined by specific alleles of the chicken tvb locus. Recently, a chicken gene that encodes a cellular receptor, designated CAR1, specific for subgroups B and D ALV was cloned, and it was proposed that this gene was the s3 allele of tvb (J. Brojatsch, J. Naughton, M. M. Rolls, K. Zingler, and J. A. T. Young, Cell 87:845-855, 1996). We now report that in a backcross derived from an F1 (Jungle Fowl x White Leghorn [WL]) male mated with inbred WL females, the cloned ALV receptor gene cosegregated with two markers linked to tvb. The two markers used were a tvb(s1)-specific antigen recognized by the chicken R2 alloantiserum and restriction fragment length polymorphisms associated with the expressed sequence tag com152e. With all three markers, no crossovers were observed among 52 backcross progeny tested and LOD linkage scores of 15.7 were obtained. These data demonstrate that CAR1 is the subgroup B and D ALV susceptibility gene located at tvb(s3).

摘要

宿主对B、D和E亚群禽白血病病毒（ALV）的易感性由鸡tvb基因座的特定等位基因决定。最近，克隆了一个编码细胞受体的鸡基因，命名为CAR1，它对B和D亚群ALV具有特异性，有人提出该基因是tvb的s3等位基因（J. Brojatsch、J. Naughton、M. M. Rolls、K. Zingler和J. A. T. Young，《细胞》87:845 - 855，1996年）。我们现在报告，在一个由F1（原鸡×白来航鸡[WL]）雄性与近交WL雌性杂交产生的回交群体中，克隆的ALV受体基因与两个与tvb连锁的标记共分离。所使用的两个标记是鸡R₂同种抗血清识别的tvb(s1)特异性抗原和与表达序列标签com152e相关的限制性片段长度多态性。对于所有这三个标记，在测试的52个回交后代中均未观察到交叉，并获得了15.7的LOD连锁分数。这些数据表明，CAR1是位于tvb(s3)的B和D亚群ALV易感性基因。