Bellometti S, Giannini S, Sartori L, Crepaldi G
Centro Studi Termali Pietro D'Abano, Abano Terme, Italy.
Int J Clin Pharmacol Res. 1997;17(4):149-53.
Osteoarthritis is an important rheumatic condition characterized by the progressive destruction of cartilage. The pathophysiologic phenomena leading to the pathologic changes in the joint appear to result from biomechanical factors and activation of final common pathways of tissue damage influencing chondrocyte homeostasis and a functional program. Several cytokines and growth factors are reported to be responsible for inflammation and cartilage degradation. Among these, IL-1 and TNF alpha have been suggested as important in promoting cartilage inflammation and tissue destruction, while IGF I has a protective influence on cartilage structure. Chondrocytes and their metabolism have gained interest as targets of drug intervention; the results of this study confirm that mud bath therapy is also able to influence chondrocyte activities. Our data suggest that mud bath therapy influences cytokines related to osteoarthrosis pathomechanism and maintenance, and encourage further investigations to evaluate possible synergism between pharmacological treatment and mud bath therapy.
骨关节炎是一种以软骨进行性破坏为特征的重要风湿性疾病。导致关节病理变化的病理生理现象似乎是由生物力学因素以及影响软骨细胞内环境稳定和功能程序的组织损伤最终共同途径的激活所引起的。据报道，几种细胞因子和生长因子与炎症和软骨降解有关。其中，白细胞介素-1和肿瘤坏死因子α被认为在促进软骨炎症和组织破坏方面很重要，而胰岛素样生长因子I对软骨结构有保护作用。软骨细胞及其代谢作为药物干预的靶点受到了关注；本研究结果证实泥浴疗法也能够影响软骨细胞的活性。我们的数据表明泥浴疗法会影响与骨关节炎发病机制和维持相关的细胞因子，并鼓励进一步研究以评估药物治疗和泥浴疗法之间可能存在的协同作用。
