Codish Shlomi, Abu-Shakra Mahmoud, Flusser Daniel, Friger Michael, Sukenik Shaul
Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Rheumatol Int. 2005 Jan;25(1):49-54. doi: 10.1007/s00296-003-0402-4. Epub 2003 Nov 14.
The aim of this study was to evaluate the efficacy of home treatment with mud compresses for the hands of patients with rheumatoid arthritis (RA).
Forty-five patients suffering from RA were enrolled in a double-blind, randomized, controlled study. Twenty-two were treated with true mud compresses (treatment group) and 23 were treated with attenuated mud compresses (control group). The compresses were applied in the patients' homes five times a week during a 3-week period. Patients were assessed four times: at baseline, upon completion of the 3-week treatment period, 1 month after the treatment, and 3 months after conclusion of the treatment period. Positive response was defined as reductions of 30% or more in the number of tender and swollen joints, 20% or more in physician global assessment of disease activity, and 20% or more in patient global assessment of the severity of joint pain.
In the treatment group, significant reductions in the number of swollen and tender joints and patients' global assessments of pain severity was observed at all post-treatment assessments. Significant improvement in the scores of physician global assessment was seen at the end of therapy and 1 month later. In the control group, no improvement in the number of swollen and tender joints or physician global assessment was found in any post-treatment evaluation. However, a significant reduction in patient global assessment of joint pain severity was reported at the end of therapy and 3 months after concluding treatment.
Treatment with mud compresses relieves pain affecting the hands and reduces the number of swollen and tender joints in the hands of patients suffering from RA. This treatment can augment conventional medical therapy in these patients.
本研究旨在评估泥敷在家治疗类风湿关节炎（RA）患者手部的疗效。
45例RA患者纳入一项双盲、随机、对照研究。22例接受真泥敷治疗（治疗组），23例接受减效泥敷治疗（对照组）。在3周内，每周5次在患者家中进行泥敷。对患者进行4次评估：基线时、3周治疗期结束时、治疗后1个月以及治疗期结束后3个月。阳性反应定义为压痛和肿胀关节数量减少30%或更多、医生对疾病活动的整体评估改善20%或更多、患者对关节疼痛严重程度的整体评估改善20%或更多。
治疗组在所有治疗后评估中，肿胀和压痛关节数量以及患者对疼痛严重程度的整体评估均显著降低。治疗结束时和1个月后，医生整体评估得分有显著改善。在对照组中，任何治疗后评估均未发现肿胀和压痛关节数量或医生整体评估有改善。然而，在治疗结束时和治疗结束后3个月，患者对关节疼痛严重程度的整体评估显著降低。
泥敷治疗可缓解RA患者手部疼痛，减少手部肿胀和压痛关节数量。这种治疗可增强这些患者的常规药物治疗效果。
