乳腺癌骨转移：正电子发射断层扫描测量的18F-氟化物摄取与CT的相关性
Skeletal metastases from breast cancer: uptake of 18F-fluoride measured with positron emission tomography in correlation with CT.
作者信息
Petrén-Mallmin M, Andréasson I, Ljunggren O, Ahlström H, Bergh J, Antoni G, Långström B, Bergström M
机构信息
Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
出版信息
Skeletal Radiol. 1998 Feb;27(2):72-6. doi: 10.1007/s002560050340.
OBJECTIVE
To characterise the uptake of 18F in skeletal metastases from breast cancer using positron emission tomography (PET) and to relate these findings to the appearance on CT.
PATIENTS AND DESIGN
PET with 18F and CT were performed in five patients with multiple skeletal metastases from breast cancer. The CT characteristics were analysed in areas with high uptake on the PET study. Dynamic PET imaging of the skeletal kinetics of the 18F-fluoride ion were included.
RESULTS
The areas of abnormal high accumulation of 18F correlated well with the pathological appearance on CT. Lytic as well as sclerotic lesions had markedly higher uptake than normal bone, with a 5-10 times higher transport rate constant for trapping of the tracer in the metastatic lesions than in normal bone.
CONCLUSION
PET with 18F-fluoride demonstrates very high uptake in lytic and sclerotic breast cancer metastases.
目的
利用正电子发射断层扫描（PET）对乳腺癌骨转移灶中¹⁸F的摄取情况进行特征描述，并将这些发现与CT表现相关联。
患者与设计
对5例患有多发性乳腺癌骨转移的患者进行了¹⁸F PET和CT检查。对PET研究中高摄取区域的CT特征进行了分析。纳入了¹⁸F-氟离子骨骼动力学的动态PET成像。
结果
¹⁸F异常高积聚区域与CT上的病理表现密切相关。溶骨性及硬化性病变的摄取明显高于正常骨，转移灶中示踪剂捕获的转运速率常数比正常骨高5至10倍。
结论
¹⁸F-氟化物PET显示溶骨性和硬化性乳腺癌转移灶摄取非常高。
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