血小板衍生生长因子-A（PDGF-A）在胃癌中的预后价值
Prognostic value of platelet-derived growth factor-A (PDGF-A) in gastric carcinoma.
作者信息
Katano M, Nakamura M, Fujimoto K, Miyazaki K, Morisaki T
机构信息
Department of Surgery, Saga Medical School, Nabeshima, Japan.
出版信息
Ann Surg. 1998 Mar;227(3):365-71. doi: 10.1097/00000658-199803000-00008.
OBJECTIVE
Because our previous study indicated that PDGF-A mRNA expression in biopsy specimens might identify a subgroup of high-risk patients with gastric carcinoma, in this study we analyzed the prognostic value of platelet-derived growth factor-A (PDGF-A) gene expression in gastric carcinoma biopsy specimens.
METHODS
Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to analyze the PDGF-A gene expression in 65 gastric carcinoma endoscopic biopsy specimens. The 65 patients were divided into a PDGF-A-positive group (29 patients) and a PDGF-A-negative group (36 patients).
RESULTS
On the basis of 2-year follow-up data, the PDGF-A-positive group demonstrated a shorter overall survival rate compared with the PDGF-A-negative group (p < 0.0001). A similar correlation was found in 34 advanced-stage patients (p = 0.003) and in 24 advanced-stage patients who underwent a curative resection (p = 0.003). Multivariance analysis indicated that the transcription of PDGF-A gene is a potent prognostic factor that is independent of the traditional pathologic parameters.
CONCLUSIONS
Expression of PDGF-A mRNA in gastric biopsy specimens may be a new preoperative prognostic parameter in gastric carcinoma.
目的
由于我们之前的研究表明，活检标本中血小板源性生长因子-A（PDGF-A）mRNA的表达可能识别出一组高危胃癌患者，因此在本研究中，我们分析了胃癌活检标本中血小板源性生长因子-A（PDGF-A）基因表达的预后价值。
方法
采用逆转录聚合酶链反应（RT-PCR）分析65例胃癌内镜活检标本中PDGF-A基因的表达。这65例患者被分为PDGF-A阳性组（29例）和PDGF-A阴性组（36例）。
结果
根据2年随访数据，PDGF-A阳性组的总生存率低于PDGF-A阴性组（p<0.0001）。在34例晚期患者（p=0.003）和24例接受根治性切除的晚期患者中也发现了类似的相关性（p=0.003）。多变量分析表明，PDGF-A基因的转录是一个独立于传统病理参数的有力预后因素。
结论
胃癌活检标本中PDGF-A mRNA的表达可能是胃癌术前一个新的预后参数。
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