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一种免疫相关基因对特征可预测浆液性卵巢癌的总生存期。

An immune-related gene pairs signature predicts overall survival in serous ovarian carcinoma.

作者信息

Zhang Liuyan, Zhu Ping, Tong Yao, Wang Yuzhuo, Ma Haifen, Xia Xuefei, Zhou Yu, Zhang Xingguo, Gao Feng, Shu Peng

机构信息

Department of Obstetrics, Beilun People's Hospital, Ningbo, People's Republic of China.

Department of Gynecology, CangZhou People's Hospital, CangZhou, People's Republic of China.

出版信息

Onco Targets Ther. 2019 Aug 28;12:7005-7014. doi: 10.2147/OTT.S200191. eCollection 2019.

DOI:10.2147/OTT.S200191
PMID:31695415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6718165/
Abstract

BACKGROUND

Ovarian cancer has the highest death rate of all fatal gynecological cancers. Increasing evidence has depicted the correlation between serous ovarian carcinoma prognosis and immune signature. Therefore, the aim of this study is to develop a robust prognostic immune-related gene pairs (IRGPs) signature for estimating overall survival (OS) of HGSOC.

METHODS

Gene expression profiling and clinical information of serous ovarian carcinoma patients were derived from three public data sets, divided into training and validation cohorts. Immune genes significantly associated with prognosis were selected.

RESULTS

Among 1,534 immune genes, a 20 IRGPs signature was built which was significantly associated with OS in the training cohort (=1.44×10; hazard ratio [HR] =3.05 [2.26, 4.10]). In the validation datasets, the IRGPs signature significantly divided patients into high- vs low- risk groups considering their prognosis (=4.30×10; HR =1.48 [1.13, 1.95]) and was prognostic in multivariate analysis. Functional analysis showed that several biological processes, including EMT and TGF-β related pathways, enriched in the high-risk group. Macrophages M2 was significantly higher in the high-risk group compared with the low-risk group.

CONCLUSION

We successfully constructed a robust IRGPs signature with prognostic values for serous ovarian carcinoma, providing new insights into post-operational treatment strategies.

摘要

背景

卵巢癌是所有致命妇科癌症中死亡率最高的。越来越多的证据表明浆液性卵巢癌预后与免疫特征之间存在关联。因此，本研究的目的是开发一种强大的预后免疫相关基因对（IRGPs）特征，用于评估高级别浆液性卵巢癌（HGSOC）的总生存期（OS）。

方法

浆液性卵巢癌患者的基因表达谱和临床信息来自三个公共数据集，分为训练队列和验证队列。选择与预后显著相关的免疫基因。

结果

在1534个免疫基因中，构建了一个包含20个IRGPs的特征，该特征在训练队列中与OS显著相关（=1.44×10；危险比[HR]=3.05[2.26，4.10]）。在验证数据集中，考虑到患者的预后，IRGPs特征显著将患者分为高风险组和低风险组（=4.30×10；HR=1.48[1.13，1.95]），并且在多变量分析中具有预后意义。功能分析表明，包括上皮-间质转化（EMT）和转化生长因子-β（TGF-β）相关途径在内的几个生物学过程在高风险组中富集。高风险组中的M2巨噬细胞明显高于低风险组。

结论

我们成功构建了一个对浆液性卵巢癌具有预后价值的强大IRGPs特征，为术后治疗策略提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/4784a69fef93/OTT-12-7005-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/0375bea92336/OTT-12-7005-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/c36de726ece4/OTT-12-7005-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/c4ded2193cdd/OTT-12-7005-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/9fefa29b555d/OTT-12-7005-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/c1cc39a38ecc/OTT-12-7005-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/4784a69fef93/OTT-12-7005-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/0375bea92336/OTT-12-7005-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/c36de726ece4/OTT-12-7005-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/c4ded2193cdd/OTT-12-7005-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/9fefa29b555d/OTT-12-7005-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/c1cc39a38ecc/OTT-12-7005-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a33/6718165/4784a69fef93/OTT-12-7005-g0006.jpg

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本文引用的文献

1
g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update).g:Profiler：一个用于功能富集分析和基因列表转换的网络服务器（2019 更新）。
Nucleic Acids Res. 2019 Jul 2;47(W1):W191-W198. doi: 10.1093/nar/gkz369.
2
A panel of three oxidative stress-related genes predicts overall survival in ovarian cancer patients received platinum-based chemotherapy.一组三个与氧化应激相关的基因可预测接受铂类化疗的卵巢癌患者的总生存期。
Aging (Albany NY). 2018 Jun 17;10(6):1366-1379. doi: 10.18632/aging.101473.
3
The prognostic value of perioperative, pre-systemic therapy CA125 levels in patients with high-grade serous ovarian cancer.
胰岛素样生长因子2受体是一个关键的免疫相关基因，与三阴性乳腺癌患者的不良预后相关：一项生物信息学分析。
Front Oncol. 2022 Oct 18;12:871786. doi: 10.3389/fonc.2022.871786. eCollection 2022.
4
Identification of an immune-related gene pair signature in breast cancer.乳腺癌中免疫相关基因对特征的鉴定
Transl Cancer Res. 2022 Jun;11(6):1523-1533. doi: 10.21037/tcr-21-2309.
5
Immune Subtype Profiling and Establishment of Prognostic Immune-Related lncRNA Pairs in Human Ovarian Cancer.免疫亚型分析和建立人类卵巢癌预后相关免疫 lncRNA 对。
Comput Math Methods Med. 2022 May 5;2022:8338137. doi: 10.1155/2022/8338137. eCollection 2022.
6
A 25 Immune-Related Gene Pair Signature Predicts Overall Survival in Cervical Cancer.一个由25个免疫相关基因对组成的特征可预测宫颈癌的总生存期。
Cancer Inform. 2022 Apr 19;21:11769351221090921. doi: 10.1177/11769351221090921. eCollection 2022.
7
Prognostic immunologic signatures in epithelial ovarian cancer.上皮性卵巢癌的预后免疫特征
Oncogene. 2022 Mar;41(10):1389-1396. doi: 10.1038/s41388-022-02181-5. Epub 2022 Jan 14.
8
Development and Validation of an Immune-Related Gene Pairs Signature in Grade II/III Glioma.II/III级胶质瘤中免疫相关基因对特征的开发与验证
Int J Gen Med. 2021 Nov 23;14:8611-8620. doi: 10.2147/IJGM.S335052. eCollection 2021.
9
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Ann Transl Med. 2021 Oct;9(20):1591. doi: 10.21037/atm-21-5217.
10
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4
A 2-Protein Signature Predicting Clinical Outcome in High-Grade Serous Ovarian Cancer.一种预测高级别浆液性卵巢癌临床结局的双蛋白标志物
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5
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Biomed Pharmacother. 2017 Nov;95:55-61. doi: 10.1016/j.biopha.2017.08.003. Epub 2017 Aug 18.
6
Development and Validation of an Individualized Immune Prognostic Signature in Early-Stage Nonsquamous Non-Small Cell Lung Cancer.早期非鳞状非小细胞肺癌个体化免疫预后标志物的建立与验证。
JAMA Oncol. 2017 Nov 1;3(11):1529-1537. doi: 10.1001/jamaoncol.2017.1609.
7
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Gynecol Oncol. 2016 May;141(2):293-302. doi: 10.1016/j.ygyno.2016.03.008. Epub 2016 Mar 16.
8
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9
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Oncotarget. 2016 Jan 12;7(2):1486-99. doi: 10.18632/oncotarget.6429.
10
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