脑脊液中的神经丝蛋白：多发性硬化症活动的潜在标志物。
Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis.
作者信息
Lycke J N, Karlsson J E, Andersen O, Rosengren L E
机构信息
Institute of Clinical Neuroscience, Department of Neurology, Göteborg University, Sahlgrenska University Hospital, Sweden.
出版信息
J Neurol Neurosurg Psychiatry. 1998 Mar;64(3):402-4. doi: 10.1136/jnnp.64.3.402.
The neurofilament protein is a major structural protein of neurons and a marker for axonal damage. The concentrations of the light subunit of the neurofilament triplet protein (NFL) in CSF were significantly increased in patients with relapsing-remitting multiple sclerosis compared with healthy controls (p<0.001). Seventy eight per cent of patients with multiple sclerosis showed increased NFL concentrations. Significant correlations between the NFL concentration in CSF and clinical indices were discerned for disability, exacerbation rate, and time from the start of the previous exacerbation to the time of the lumbar puncture. The results suggest that axonal damage occurs during relapsing-remitting multiple sclerosis and that the damage contributes to disability and the appearance of clinical exacerbations. The concentration of NFL in CSF is a potential marker of disease activity in multiple sclerosis and might be useful in future clinical trials of multiple sclerosis.
神经丝蛋白是神经元的一种主要结构蛋白，也是轴突损伤的标志物。与健康对照相比，复发缓解型多发性硬化患者脑脊液中神经丝三联体蛋白轻链亚基（NFL）的浓度显著升高（p<0.001）。78%的多发性硬化患者NFL浓度升高。脑脊液中NFL浓度与残疾程度、病情加重率以及从上一次病情加重开始到腰椎穿刺时的时间等临床指标之间存在显著相关性。结果表明，复发缓解型多发性硬化期间会发生轴突损伤，且这种损伤会导致残疾和临床病情加重。脑脊液中NFL浓度是多发性硬化疾病活动的潜在标志物，可能对未来的多发性硬化临床试验有用。
Zotero 插件